Low temperature
Gentle processing for heat-sensitive products.
Supercritical CO₂, engineered for industry
Above 31 °C and 74 bar, CO₂ becomes supercritical: it has the density of a liquid and the diffusivity of a gas. It is non-toxic and inert, and it leaves no residue when it returns to a gas. Biotech One turns these properties into robust, scalable industrial processes
31 °C
supercritical
74 bar
pressure
35 °C
EncapX®
Why scCO₂
A clean fluid with industrial leverage
Penetrating power
The diffusivity of a gas with the density of a liquid.
Selectivity
Tunable solvent power through pressure and temperature.
No residue
CO₂ returns to a gas and leaves no unwanted by-products.
How EncapX® works
Feed. Form. Collect
A continuous millifluidic path, pinned as you scroll
01
Feed
Lipids, your active ingredient and an aqueous phase enter the system with supercritical CO₂.
Pressure and flow rates set the starting conditions.
02
Form
In pressure-controlled millifluidic channels, vesicles self-assemble around the active ingredient, continuously, at 35 °C.
Channels about 1,000 times wider than microfluidic chips keep the process clog-free while the bilayer closes around the gold core.
03
Collect
CO₂ returns to a gas and leaves no residue. Uniform nanoliposomes or LNPs come out ready for formulation.
Particle size, distribution and encapsulation efficiency are measured on the collected stream.
Millifluidics, not microfluidics
Wider channels. Continuous runs. Same process at every scale
Microfluidic chips use micrometre channels that clog and must be multiplied to scale up. EncapX® uses pressure-controlled millifluidic tubes about 1,000 times wider, so production runs continuously, without clogging, and scales without changing the process. Whatever the target scale, EncapX® forms the same particles: industrial scale is reached by multiplying the same device, not by redeveloping the process.
01
Feed
02
Form
03
Collect
Other CO₂ platforms
Extraction and sterilisation, for R&D partnerships
Encapsulation and sterilisation can be combined on the same supercritical CO₂ platform, a topic of our June 2026 technical webinar.
R&D partnerships
Extract-X®
Continuous extraction directly from wet biomass (microalgae, yeasts, bacteria): no drying, no toxic solvents, mild temperatures, oxygen-free processing.
R&D partnerships
Sterili-X®
Low-temperature CO₂ sterilisation and decontamination of heat-sensitive materials and medical devices.
Let's talk
Discuss a process with our team
Whether you need encapsulation, extraction or sterilisation, we can map the right path