Fabien Balme
CEO & CTO · engineer, over 35 years as a senior executive at Siemens and serial entrepreneur with a healthcare exit
Supercritical CO₂ solutions for industrial applications
Biotech One is a deep tech technology provider. We design and deliver clean, competitive supercritical CO₂ process platforms that manufacturers can run in their own production environments, from R&D to full-scale manufacturing
Biotech One designs and builds its technology in France and contributes to sovereign biomanufacturing, as a member of France BioLead.
Redefining Encapsulation & Extraction with CO₂ Technology
In the media
Fabien Balme interviewed by Planète Ingénieur
Why encapsulating fragile molecules such as RNA is an industrial challenge, and how a patented process becomes a ready-to-use machine.
Milestones
From Marseille lab to industrial deployment
2022
Biotech One is founded in Marseille. Bpifrance French Tech grant for R&D on scCO₂ encapsulation.
2023
First commercial contracts in the chemistry and cosmetics industries.
2024
Technology validated through collaborations with major industrial groups. Exclusive licence on continuous algae extraction patents.
2025
First commercial order for an EncapX® system. EncapX® patent validated. Région Sud Investissement and CAAP Création join the capital (€1M round). Laureate of the Horizon Europe "Alliance" project (48 months, €8.75M in total).
2026
€1M round announced to industrialise EncapX® and Extract-X® · joined France BioLead and ETPN · talks at World Vaccine Congress Europe, BIOPC and the LNP Development Summit Europe · COSMETIC 360 Innovation Award (Industry & Process) and REGENERATIONS Jury's Coup de cœur.
Team
Engineers, scientists and industry veterans
EK
Dr Elissandro Klein
R&D Project Manager · PhD in Chemical Engineering, supercritical fluids expert
Dr Marcelo Kravicz
PhD in Nanomedicine · RNA delivery and scalable nanoencapsulation
Dr Sandra Robelet
Scientific Ambassador · PhD in Neurosciences, 20+ years across CRO, biopharma and business development
Jean-Christophe Ozenne
MBA · sterilisation applications and industrial deployment, 20+ years in medical devices
Jade Simon
Biology engineer · market consultant for microalgae-based ingredients
Scientific advisory board
Guidance rooted in supercritical fluids
Scientific advisor
Prof. Elisabeth Badens
PhD in Chemical Engineering · Editor-in-Chief of The Journal of Supercritical Fluids · Full Professor at Aix-Marseille University
Scientific advisor
Prof. Feral Temelli
Nutraceuticals expert · Associate Editor of The Journal of Supercritical Fluids
Scientific advisor
Dr Iago Dominguez Teles
Microalgae expert · Research Manager at Wageningen University
Scientific advisor
Dr Omar Salman
PhD in Chemical Engineering · recognised for his role in developing key components of the Pfizer-BioNTech COVID-19 vaccine
Ecosystem & funding
Supported for the long run
Biotech One is supported by the European Union (Horizon Europe), Région Sud, Région Sud Investissement, CAAP Création and Bpifrance. Member of ETPN (European Technology Platform on Nanomedicine), France BioLead, the Bio-based Industries Consortium, AFSSI Sciences de la Vie and Eurobiomed.
Supported by
Careers
We are growing
Scientists and engineers who want to industrialise clean processes are welcome to send a spontaneous application.
